產(chǎn)品信息

TGF-β家族成員廣泛存在于從果蠅到人多種生物的 各種組織中，對(duì)正常細(xì)胞、癌變細(xì)胞都有著顯著作用。TGF-β除了影響細(xì)胞的增殖、分化，還在胚胎發(fā)育、胞外基質(zhì)形成、 骨的形成和重建等方面起著重要作用。

A83-01:
A selective inhibitor of ALK-4 (Activin/Nodal receptor), ALK-5 (TGF-β type I receptor), and ALK-7 (nodal receptor). Only weakly inhibits ALK-1, -2, -3, and -6. 3-(6-METHYLPYRIDIN-2-YL)-1-PHENYLTHIOCARBAMOYL-4-QUINOLIN-4-YLPYRAZOLE

Ref: Tojo, M., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 96: 791-800, 2005.

Purity:
Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Not determined.

重慶市華雅干細(xì)胞技術(shù)有限公司